laiv

2024-05-14


We believe this study provides compelling evidence that the LAIV can provide a significant reduction in infection and symptoms when challenged with heterosubtypic influenza strains not included in ...

Children 6 months through 8 years of age may need 2 doses during a single flu season. Everyone else needs only 1 dose each flu season. Live, attenuated influenza vaccine (called LAIV) is a nasal spray vaccine that may be given to non-pregnant people 2 through 49 years of age.

The null hypothesis for the study was that the proportion of children experiencing asthma exacerbation in the LAIV4 group would be ≥10% higher than the proportion in the IIV4 group. The study was designed to provide >80% power to claim noninferiority with a 1-sided α of 0.05.

Our data provides evidence that the effect of LAIV on S pneumoniae density in children residing in an area of high pneumococcal carriage is modest and supports the wider rollout of LAIV in LMICs to help reduce the burden of influenza-related morbidity and mortality.

The LAIV can provide up to 90% protection in adults under 65 years of age, and up to 40% of adults over 65 (though inactivated vaccines are preferred for older individuals).

We found that LAIV and IIV were safe and moderately efficacious against laboratory-confirmed influenza virus infection. In Year 1, LAIV, as a single dose in a vaccine-naïve population, was significantly less efficacious than IIV, whereas in Year 2, VE for LAIV and IIV was similar.

Qi Tony Zhou. Pharmaceutical Research (2023) Influenza viruses cause annual seasonal epidemics and sporadic pandemics; vaccination is the most effective countermeasure. Intranasal live attenuated ...

Live attenuated influenza vaccine (LAIV) is a type of influenza vaccine in the form of a nasal spray that is recommended for the prevention of influenza. It was developed by the Syrian-American epidemiologist Hunein Maassab .

The recent wave of epidemic may also affect the vaccination plans for members of the public and thus a limited quantity of LAIV remains available. Compared to quadrivalent inactivated influenza vaccines, LAIV has more restrictions in administration of vaccines with a shorter shelf-life.

Summary of Data Reviewed. Review of LAIV effectiveness data for previous seasons in the United States confirms low to no significant effectiveness of LAIV against influenza A (H1N1)pdm09-like viruses. However, LAIV was generally effective against influenza B viruses and was of similar effectiveness to IIV against influenza A (H3N2) viruses.

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